The most common side effects of STALEVO are unwanted or uncontrollable movements (known as dyskinesia), nausea, diarrhea, excessive muscle movements (known as hyperkinesia), harmless discoloration of urine, sweat and/or saliva; diminished or slow movements (known as hypokinesia), abdominal pain, dizziness, constipation, fatigue, pain, and hallucinations. Some of the more serious side effects may include severe diarrhea, severe dyskinesia, hallucinations, other mental disturbances, orthostatic hypotension (low blood pressure), rhabdomyolysis (a muscle disease), and symptoms resembling neuroleptic malignant syndrome (a condition characterized by fever and muscle stiffness).

Be careful using STALEVO if you have severe heart or lung disease, asthma, renal, hepatic, or endocrine disease, or a history of heart attacks or ulcers. Do not take STALEVO if you have glaucoma, melanoma, or other related medical disorders.

In some people, STALEVO may cause urine or sweat to change color, becoming brownish orange. STALEVO may also cause saliva to darken. These are harmless side effects and are not cause for concern, although sweat may stain clothes.

Drugs broken down by the COMT enzyme (eg, isoproterenol, epinephrine) should be used with caution when taking STALEVO. If you take a nonselective monoamine oxidase (MAO) inhibitor, you should not take STALEVO. STALEVO should not be taken with selegiline at doses higher than 10 mg/day.

Before you take STALEVO, talk to your doctor about any health problems you might have. For more information about STALEVO, read the full prescribing information. The prescribing information will explain how STALEVO will act in your body, possible side effects, drug interactions, and precautions.