The most common side effects of STALEVO include dyskinesias (uncontrolled movements), nausea, an increase in movement (called hyperkinesia), change in the color of your urine, diarrhea, and stomach pain. Some serious side effects may include diarrhea, sometimes severe; colitis (inflammation of the large intestine), which may be caused by prolonged diarrhea; severe dyskinesia; hallucinations; other mental disturbances; orthostatic hypotension (low blood pressure upon rising rapidly after sitting or lying down with or without symptoms such as dizziness, nausea, fainting, and sweating); rhabdomyolysis (a muscle disease); and symptoms resembling neuroleptic malignant syndrome (a condition characterized by high fever, muscle stiffness, and confusion); a lung condition called fibrosis; and skin cancer.

Be careful using STALEVO if you have severe heart or lung disease; asthma; renal, hepatic, or endocrine disease; or a history of heart attacks or ulcers. Do not take STALEVO if you have a history of, or currently have, active skin cancer or abnormal skin growths, glaucoma, melanoma, or other related medical disorders.

Patients should be observed for any development of intense urges (eg, gambling, sexual urges) and the inability to control these urges while taking STALEVO.

In some people, STALEVO may cause urine or sweat to change color, becoming brownish-orange. STALEVO may also cause saliva to darken. These are harmless side effects and are not cause for concern, although sweat may stain clothes.

Drugs broken down by the COMT enzyme (eg, isoproterenol, epinephrine) should be used with caution when taking STALEVO. If you take a nonselective monoamine oxidase (MAO) inhibitor, you should not take STALEVO. STALEVO should not be taken with selegiline at doses higher than 10 mg/day.

Before you take STALEVO, talk to your doctor about any health problems you might have. For more information about STALEVO, read the full Prescribing Information. The Prescribing Information will explain how STALEVO will act in your body, possible side effects, drug interactions, and precautions.